Subsequently, they analyzed gene expression profiles of SLE patients with different histological types of LN who underwent repeated renal biopsies and found that tubulointerstitial CXCL10 expression decreased when the disease changed from proliferative or mixed nephritis to membranous nephropathy and correlated with the histological activity index; however, there was no difference in glomerular and tubulointerstitial CXCL10 expression between LN patients and controls [88]. The gene discussed is CXCL10; the disease is systemic lupus erythematosus.