Hence, based on bioinformatic analysis of the GSE46955 data [13], we conducted this study to investigate the inflammatory response characteristics of the functional disability in monocytes through the transcription activator hypoxia-inducible factor-1α (HIF-1α) in mediating the protein signal transducer and activator of transcription 3 (STAT3) during the severe pneumonia with sepsis. The gene discussed is HIF1A; the disease is Sepsis.