Conversely, in the clinical study, the expression of protein PD-L1 was upregulated in the late phase of sepsis, while, in the animals' study, the protein PD-L1 expression was higher in the sepsis rat model group compared with the Ade-control group and the Ade-HIF-1α group (Figure 3). The gene discussed is HIF1A; the disease is Sepsis.