COX2 is induced by proinflammatory and infectious agents and is responsible for the conversion of arachidonic acid into prostaglandin (PG)E2 [5], which is actively involved in tissue damages by changing the connective tissue metabolism and by enhancing osteoclastic bone resorption, showing an evident association with the tissue destruction during periodontal disease progression [6, 7]. Here, PTGS2 is linked to periodontal disorder.