CTLA4 and Graves disease: The SNPs rs3087243 (A/G) and rs11571316 (A/G) of the human CTLA4 (cytotoxic T-lymphocyte antigen4) gene on chromosome 2q33 have been associated with susceptibility to autoimmune disease, e.g., type 1 diabetes, Graves’ disease, autoimmune hypothyroidism, systemic lupus, and Addison’s disease [35–42].