In addition, there are reports that interferon beta (IFN-β) is significantly better than IFN-α and also that polyethylene glycol-modified IFN-α prevented SARS-CoV infection, reduced viral replication, and reduced histopathology during treatment (Cinatl et al., 2003b; Haagmans et al., 2004). Here, IFNB1 is linked to severe acute respiratory syndrome.