On the contrary, TRPM8 activation reversed meningeal inflammation-induced lowering of the facial heat pain threshold, and in a trigeminal ganglion cell assay TRPM8 activation inhibited TRPV1 effects, which raised speculations about an antinociceptive activity of TRPM8 in migraine (Kayama et al. 2017). The gene discussed is TRPM8; the disease is migraine disorder.