Moreover, PART pathology may be on a continuum with the tau pathology of AD, as both involve deposition of 3R/4R tau isoforms in the entorhinal cortex and hippocampus in neurofibrillary tangles (NFTs); however PART by definition lacks amyloid-β pathology (NFT+/Aβ−) [10, 12]. Here, MAPT is linked to Alzheimer disease.