In contrast, brains that either lacked immunohistochemically detectable tau pathology, e.g. a cerebrovascular disease (CVD) case, or had 4R tau pathology (a PSP case), seeded fibrillization of K12CFh at only 10− 3 – 10− 5 dilution of brain homogenate. The gene discussed is MAPT; the disease is cerebrovascular disorder.