The highlight of our finding is that we demonstrate for the first time that PLAGL2, a TF that has previously been recognized as an important regulator of cell fate [36], plays a key role in modulating neroblastoma cell differentiation via interacting with three well-recognized differentiation-regulating molecules of neuroblastoma cells, MYCN, RA and miR-506-3p [17, 20, 37, 38]. The gene discussed is MYCN; the disease is neuroblastoma.