PLAGL2 and neuroblastoma: Therefore, following the discovery of the interplay between PLAGL2, MYCN and miR-506-3p, we further investigated the function of PLAGL2 in regulating neuroblastoma cell differentiation and the possible involvement of this interplay network in mediating the cellular function of RA, and investigated the clinical relevance of PLAGL2 in determining neuroblastoma prognosis.