NFKB1 and Hyperammonemia: Hyperammonemia strongly altered the intracellular distribution of p50, increasing the nuclear/cytosolic ratio (0.56 ± 0.03) compared to that in control rats (0.37 ± 0.02) (Fig. 5a, c) and strongly reducing the level of p50 in the nucleolus (Fig. 5a, d).