One breast cancer patient had a PTPN11 mutation in the primary tumor that was not identified in the metastatic tumor, another breast cancer patient had an ERBB2 mutation in the metastatic tumor that was not identified in the primary tumor, and one lung cancer patient had a MAP3K13 mutation in the metastatic tumor that was not identified in the primary tumor (Additional file 1: Table S7). This evidence concerns the gene PTPN11 and metastatic neoplasm.