In addition to BMI and ALB, two comprehensive indicators prognostic nutritional index (PNI) which includes albumin and lymphocyte and nutritional risk index (NRI) which combines weight, height and serum albumin levels, have also been reported as simple but sensitive methods that can objectively assess the nutritional status of cancer patients and predict their prognosis in esophageal squamous cell carcinoma, liver cancer, lung cancer, and gastric cancer et al. [11, 14–19]. The gene discussed is ALB; the disease is liver cancer.