TNFSF11 and osteoporosis: RANKL is a key link between reduced oestrogen levels and osteoclast‐mediated bone loss in post‐menopausal women.52, 53, 54 Briefly, RANKL is involved in the differentiation and activation of osteoclasts, while OPG is associated with osteoclasts inhibition and apoptosis.55 Data from transgenic animals have shown that overexpression of RANKL can result in osteoporosis.