PTCH1 and rhabdomyoma: Previous publications reported PTCH1‐inactivating mutations (resulting in hedgehog (Hh)‐signaling pathway activation) or a deregulation of the Hh‐signaling pathway in RMS tumors with high levels of myogenic differentiation.24, 25 As previously suggested by others,24 highly differentiated RMS tumors and rhabdomyomas might form a continuous spectrum of tumors.