That study confirmed that patients with NSCLC in the low Hb group had a poor prognosis.33 Pathak et al. evaluated 487 patients with stage I NSCLC treated with stereotactic body radiation therapy (SBRT) and reported that patients with anemia before treatment had increased local recurrence and distant metastasis rates; additionally, the OS rate of these patients was significantly lower.34 This evidence concerns the gene GSTM1 and anemia (phenotype).