TRIM72 and cardiac hypertrophy: MG53 exerts a cardioprotective effect during ischaemia-reperfusion injury through phosphorylation of GSK-3 [14, 34], and because ischaemia-reperfusion injury is also a risk factor for sudden cardiac death and heart failure and post-MI cardiac hypertrophy, MG53 has emerged as a promising target in the treatment of MI patients.