CHAER1 and cardiac hypertrophy: For instance, Chaer (Cardiac Hypertrophy-Associated Epigenetic Regulator) contributes to progression of cardiac hypertrophy by directly interacting with the catalytic subunit of polysome repressor complex 2 (PRC2), thereby inhibiting histone H3 lysine 27 methylation at the promoter region of genes involved in cardiac hypertrophy [8].