PRNP and mucopolysaccharidosis type 3A: Here, we studied amyloidogenic protein aggregation in the brain of mice with MPS-IIIA, one the most common and severe types of neurodegenerative LSDs, and found that neuronal cell bodies provide a major site for progressive deposition of multiple amyloid proteins including α-synuclein, prion protein (PrP), Tau, and amyloid-β protein (Aβ).