Hypercholesterolemia-triggered neutrophilia and mobilization of Ly6Chi monocytes from the spleen as a result of extramedullary hematopoiesis in WD-fed Apoe−/− mice have been shown to promote atherogenesis [29, 30] and reversal of neutrophilia and reduction of Ly6Chi monocytes by TG101348 likely contributes to reduced atherogenesis. This evidence concerns the gene APOE and familial hypercholesterolemia.