Although both promoter-I and promoter-IV interact with −8 superenhancer in the TAL1-negative and TAL1-positive T-ALL patient cells (Figure 3B), −31CBSinv/inv does not prevent the −8 super-enhancer to interact with the TAL1 promoters (Supplementary Figure S4A). The gene discussed is TAL1; the disease is acute lymphoblastic leukemia.