In agreement with the systemic overexpression study, HNRNPA1 overexpression following i.m. injections resulted in a shift to the fetal pattern for DM1 splicing targets including Ldb3 exon 11, Atp2a1 exon 22, Clcn1 exon 7a, Mbnl1 exon 7, Pdlim exon 5, and Tnnt3 exon F (Fig. 2 C and D). Here, HNRNPA1 is linked to myotonic dystrophy type 1.