Previous studies have demonstrated that cardiomyocyte-specific STIM1 suppression in mice results in age-dependent cardiomyopathy and heart failure in adults (Collins et al., 2014; Parks et al., 2016), whereas severe heart failure was evident during embryogenesis in zebrafish with Orai1 suppression (Volkers et al., 2012). Here, ORAI1 is linked to cardiomyopathy.