Similarly, pharmacological induction of cardiac hypertrophy by phenylephrine and endothelin-1 is attenuated by suppression of STIM1 or Orai1 in rodent cardiomyocytes (Hulot et al., 2011; Luo et al., 2012; Voelkers et al., 2010). Here, STIM1 is linked to cardiac hypertrophy.