ORAI1 and cardiac hypertrophy: For example, induction of cardiac hypertrophy by pressure overload results in upregulation of STIM1 and Orai1 expression in mouse cardiac tissue, and cardiomyocyte-specific suppression of STIM1 and Orai1 attenuates the hypertrophic response (Benard et al., 2016; Hulot et al., 2011; Luo et al., 2012; Parks et al., 2016).