For example, siRNA knockdown of STIM1 in freshly isolated neonatal rat ventricular myocytes led to a significant reduction of the caffeine-releasable SR Ca2+ pools (Voelkers et al., 2010), whereas SR Ca2+ store content was unchanged in adult cardiomyocytes isolated from STIM1-deleted mouse hearts compared to controls despite clear indication of dilated cardiomyopathy (Parks et al., 2016). Here, STIM1 is linked to dilated cardiomyopathy.