It is important to note that the highest frequency of FGFR-TACC chromosomal translocations is in HGG, namely IDH-wild type GBM where the fusion is between FGFR3 and TACC3, located 48 kb apart on chromosome 4p16 [18, 50, 69] see FGFR3 fusions). The gene discussed is TACC3; the disease is glioblastoma.