The upregulated 14 genes (A2M, FN1, MMP1, VCAN, C5ORF13, HIF1A, SERPINH1, ACAN3, TNFAIP6, INHBA, DCN, FMOD, TGF-β1, and TGF-β3) play important roles in keloid pathogenesis. This evidence concerns the gene HIF1A and keloid.