Asian keloid cells (AKCs) were significantly upregulated for the keloid and matrix assembly-related genes such as A2M, FN1, MMP1, VCAN, C5orf13, HIF1a, SERPINH1, ACAN3, TNFAIP6, INHBA, DCN, FMOD, TGF-β1, and TGF-β3; and downregulated for ANXA1, ASPN, IGFBP7, LGALS1, and PTN compared to human skin fibroblasts (HSFs). This evidence concerns the gene TNFAIP6 and keloid.