Hence, the gAChR Abs were considered as possible pathogenic humoral factor in the pathomechanism of GI dysmotility in SSc along with Abs against M3R, RNPC3, U1 snRNP, U3 snRNP, signal recognition particle, Ku, and myenteric neuron [29, 30, 44]. This evidence concerns the gene U1 and systemic sclerosis.