TUBB3 and polymicrogyria: Specific phenotypes may be more frequently associated with mutations of particular isoforms (e.g., TUBA1A to lissencephaly or TUBB2B to polymicrogyria) [11,12,13], and at the single gene level, distinct mutations can cause either polymicrogyria or axon guidance disorders (e.g., in TUBB3) [14] depending on the variant’s impact on the dynamic properties of the cytoskeleton.