TUBB and tubulinopathy: To further clarify the genotype- phenotype correlations of TUBB-related tubulinopathies, we mapped all reported mutations related to CSC-KT (p.Y222F, p.Q15K and p.M73T) and pure neurological phenotypes (p.M299V, p.V353I, p.E401K, p.N52S) in the quaternary structure of the TUBB5/α-tubulin complex.