Similarly, the RAVE trial (rituximab versus cyclophosphamide for ANCA-associated vasculitis), the largest randomized controlled trial in AAV so far, has shown a higher rate of renal involvement (79% versus 59%) and peripheral neuropathy (27% versus 15%) among patients with MPO-ANCAs than with PR3-ANCAs and the opposite pattern with constitutional symptoms (53% versus 71%), ear/nose/throat involvement (33% versus 70%), and lung nodules or cavities (12% versus 28%) [165,166]. The gene discussed is PRTN3; the disease is anti-neutrophil cytoplasmic antibody-associated vasculitis.