Of interest, the triple combination of VEGFRs artificial miRNAs, able to concurrently inactivate the three VEGFR isoforms, in pancreatic cancer cell lines (BXPC-3, MIAPACA2, Panc-1, and SW1990) and in mouse pancreatic cancer xenograft models (SW1990 cells), reduced proliferation, migration and invasion, and increased apoptosis. This evidence concerns the gene KDR and familial pancreatic carcinoma.