The levels of sVEGFR-1 also seem to play a significant role in cancer progression: in several cancer types, the VEGF-A/sVEGFR-1 ratio detected in tumor tissue, serum or plasma samples, has been shown to correlate with disease aggressiveness, malignancy grade, survival and response to the therapy [31,32,33,34,35]. This evidence concerns the gene VEGFA and cancer.