Interestingly, a difference was observed in ECM invasion between two melanoma cell clones which differed in the expression of VEGFR-2, while having comparable levels of VEGFR-1: cells with higher expression of VEGFR-2 were 8-fold more invasive, suggesting that VEGFR-2 plays a relevant role in ECM invasion triggered by VEGF-A in melanoma cells [159]. This evidence concerns the gene KDR and melanoma.