Moreover, in in vivo murine models, PlGF produced by bone marrow stromal cells stimulated angiogenesis in the bone marrow as well as CML cell growth, and treatment with the anti-murine PlGF mAb 5D11D4 prolonged the survival of CML bearing mice [282]. This evidence concerns the gene PGF and chronic myelogenous leukemia, BCR-ABL1 positive.