In summary, the present study demonstrated that deAND may reduce steatohepatitis, liver fibrosis and liver injury, upregulate Nrf-2 triggered increase in proteins and/or activities of antioxidant enzymes, and lower inflammation by attenuating NLRP3 inflammasome activation in mice fed a HFHC diet. Here, NFE2L2 is linked to Hepatic fibrosis.