As one of the mechanisms for PP2A hyperphosphorylation in eosinophilic airway inflammation, we confirmed that PTP-RR, a regulator of PP2A-Tyr307 phosphorylation [11], was reduced under stimulation with EPX and in nasal epithelial cells from ECRS patients with severe asthma (Figure S2). The gene discussed is EPX; the disease is asthma.