PSEN1 and early-onset autosomal dominant Alzheimer disease: Similarly, the same single oral daily dose of TRF (60 mg/kg) for the same duration (10 months) in AβPP/PS1 male mice (5 months of age) slightly enhanced cognitive function, and metabolomics analyses indicated an alteration in 90 putative metabolites that are involved in several metabolic Alzheimer’s disease pathways [31].