PSEN1 and early-onset autosomal dominant Alzheimer disease: Also, the same dose of TRF (60 mg/kg) for the same duration (10 months) in the same animals (AβPP/PS1 male mice) indicated a slight enhancement of the cognitive function; however, metabolomics indicated that TRF induced 90 putative metabolites that are involved in several metabolic pathways in Alzheimer’s disease [31].