APP and neuroblastoma: Furthermore, simultaneous treatment with 10 μM of α-TCT reduced the levels of hydrogen peroxide-induced ROS in human neuroblastoma cells [SH-SY5Y wild-type] [23], although the same treatment was observed to increase the levels of β-amyloid proteins in human neuroblastoma cells overexpressing the human APP695 isoform [SH-SY5Y APP] and those expressing C99 [SH-SY5Y cells] through direct stimulation of the β- and γ-secretase proteolytic enzymes.