PSEN1 and Alzheimer disease: Using a double transgenic Alzheimer’s disease (AβPP/PS1) animal model, a long-term single oral daily dose of 60 mg/kg of TRF for 10 months in male mice (5 months of age) significantly enhanced recognition abilities and reduced the deposition of β-amyloid proteins in the cortex and hippocampus (soluble and insoluble Aβ isoforms: Aβ 40, Aβ 42 and Aβ oligomer) [30].