EXO1 and Alzheimer disease: In addition, a single oral daily dose of 200 mg/kg of TRF for 6 months in AβPP/PS1 male mice (aged 9 months) upregulated the genes that are responsible for neuroprotective effects, such as Slc24a2 (solute carrier family 24 [sodium/potassium/calcium exchanger]), exo1 (exonuclease 1), and Enox1 (ecto-NOX disulfide-thiol exchanger 1), and downregulated the genes responsible for the pathology of AD, such as Pla2g4a (phospholipase A2, group IVA [cytosolic, calcium-dependent]), Tfap2b (transcription factor AP-2 beta) [35], (Table 7).