HF, heart failure; BMI, body mass index; BP, blood pressure; NYHA, New York Heart Association; LVEF, left ventricular ejection fraction; HF, heart failure; AF, atrial fibrillation; WBC, white blood cells; BUN; blood urea nitrogen; Cr, creatinine; eGFR, estimated glomerular filtration rate; BNP, brain natriuretic peptide; NT-proBNP, n-terminal brain natriuretic peptide; ACEi, angiotensin-converting-enzyme inhibitor; ARB, angiotensin II receptor blocker; Tx., therapy; TPL, transplantation. The gene discussed is NPPB; the disease is heart failure.