Mutations in emerin lead to Emery–Dreifuss muscular dystrophy [34], MAN1 mutations cause disorders affecting osteogenesis via deregulated BMP signaling [35], and LEM2 has been linked to Hutterite-type cataracts [36], arrhythmic cardiomyopathy [37] and LEMD2-associated nuclear envelopathy with progeria-like phenotype [38]. Here, LEMD2 is linked to early-onset non-syndromic cataract.