TP53 and osteosarcoma: Regarding the molecular mechanism underlying OBP-702-induced autophagy and apoptosis, the p53-inducible modulator of autophagy (DRAM) and the pro-apoptotic BCL2 associated X apoptosis regulator (BAX) proteins are upregulated, but the p53-downstream target p21 and MDM2 genes are not upregulated in OBP-702-infected osteosarcoma cells (Figure 5).