Interestingly, rheumatoid arthritis patients, being at increased risk of CVD, also exhibited low neutrophil CXCR2 expression in the synovial fluid as compared to the peripheral blood, which might be the result of recruitment of neutrophils via IL-8 signaling or the local presence of TNF-α in the synovial fluid [59]. The gene discussed is TNF; the disease is rheumatoid arthritis.