Interestingly, rheumatoid arthritis patients, being at increased risk of CVD, also exhibited low neutrophil CXCR2 expression in the synovial fluid as compared to the peripheral blood, which might be the result of recruitment of neutrophils via IL-8 signaling or the local presence of TNF-α in the synovial fluid [59]. This evidence concerns the gene CXCR2 and rheumatoid arthritis.