Recently, Clauditz et al. [40] evaluated the ALCAM protein expression in HNSCC, including LSCC samples, combining in the same group of samples laryngeal and hypopharyngeal tumors, and observed a discordant result to our findings, being ALCAM expression mainly cytoplasmic, and not associated with the prognosis of LSCC patients. The gene discussed is ALCAM; the disease is head and neck squamous cell carcinoma.