In addition, in one patient with RA, LGL γδ cells, that expressed a Vγ9-Vδ2+ phenotype, and constituted 60% of the PB T cells, did not proliferate, but did secrete TNFα when triggered with anti-CD3, and the addition of these cells to decreased their secretion of immunoglobulin (Ig) M from pokeweed mitogen-stimulated B cells from the patient, while augmenting IgG secretion [43]. The gene discussed is TNF; the disease is rheumatoid arthritis.