IL27 and arthritic joint disease: By contrast, in arthritis that does not require any antigen to induce disease, but rather is induced by injected gene transfer of IL-23 in B10.RIII mice, γδ T cell depletion with mAb decreased neutrophils in joints and spleen while increasing IL-27 production by neutrophils and activated macrophages, resulting in abrogation of the arthritis.