Finally, in one study, RA-derived Vγ9Vδ2 T cell clones, appeared to display dual antigenic recognition: a nonclonal, MHC-unrestricted recognition of mycobacteria, and a clonal recognition of a short tetanus toxin peptide presented by HLA-DRw53, a nonpolymorphic class II MHC molecule associated with susceptibility to rheumatoid arthritis. This evidence concerns the gene HLA-C and rheumatoid arthritis.