On the other hand, when PBMC from SSc patients and HCs were stimulated by increasing concentrations of zoledronate, with or without IPP, and Vγ9+ T cell percentages were calculated using FACScan analysis it was found that higher concentrations of zoledronate were required for maximal proliferation of Vγ9+ T cells in 9 SSc patients compared to 9 HCs. The gene discussed is IPP; the disease is systemic sclerosis.