In a randomized placebo-controlled clinical study, PCa middle-aged men were given two doses of resveratrol (150 or 1000 mg/day) for four months: the levels of circulating androgen precursors were shown to be reduced, but no effect was observed on testosterone, DHT, and PSA levels, as well as on prostate volume [306]. This evidence concerns the gene KLK3 and posterior cortical atrophy.