Two randomized, double-blind, placebo-controlled trials, aimed at evaluating the effects of curcumin on PCa patients undergoing radiotherapy, showed that this phenol could mitigate radiation-induced proctitis and oxidative stress [290,291], while six-month intake of the compound reduced the elevation of PSA in PCa men who received intermittent androgen deprivation (IAD), despite not significantly affecting the overall off-treatment duration of the therapy [292]. This evidence concerns the gene KLK3 and posterior cortical atrophy.