POLE2 and Fanconi anemia: Further we detected a differential regulation of Fanconi anemia-related genes (p < 10–13; ATRIP, BRCA1 EME1, ERCC1, FANCB, FANCC, FANCD2, FANCE, FANCG, RPA1, RPS27A, UBA52, UBE2T) and translesion synthesis regulating genes (p < 10–16; CUL4A, MAD2L2, POLD1, POLD2, POLD3, POLD4, POLE2, RFC3, RFC5, RPA1, RPS27A, UBA52, UBA7) in 106-HIO FANCA-deficient (Supplementary Figure S4).