In post-infarcted mice, a release of SASP factors, including CCN1, MCP1, IL-1α and TNFα, occurs in myocardium, and is mediated by GATA4: in vivo, short-hairpin RNA (shRNA) based knockdown of GATA4 inhibits SASP, and exacerbates cardiac dysfunction as well as fibrosis post-MI [43]. Here, GATA4 is linked to myocardial infarction.