Indeed, Ang2 interacted with α5β1 integrin in Tie2- deficient human glioma cells, leading to activation of focal adhesion kinase (FAK), p130Cas, extracellular signal-regulated protein kinase (ERK) 1/2, and c-jun NH2-terminal kinase (JNK) and induction of MMP-2 expression and secretion [19,72,86]. This evidence concerns the gene ANGPT2 and central nervous system cancer.