In this study, we studied venetoclax (Venclexta, Venclyxto, ABT-199, GDC-0199, RG7601), a potent and selective BCL-2 inhibitor, approved by the FDA in 2016 for the treatment of patients with chronic lymphocytic leukemia (CLL) with 17p deletion [19]. This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.