In light of the aforementioned controversial discussion around the role of α2-ARs in liver fibrosis/cirrhosis, we sought to investigate the influence of the novel α2-AR blocker mesedin (2-(2-methyl-amino-thiozolyl)-1,4-benzodioxane hydrochloride) [15] on the two main nonparenchymal liver cell types, hepatic stellate cells and liver sinusoidal endothelial cells, which are key players in the fibrotic reorganization of liver tissue and the permeability of the blood-tissue barrier during cirrhosis. The gene discussed is ADORA2A; the disease is Cirrhosis.