NPPB and type 2 diabetes mellitus: The Diabetes Prevention Program (DPP) is a completed clinical trial that randomized a multi-ethnic cohort of individuals at high risk for developing type 2 diabetes to receive placebo, lifestyle modification, or metformin.[21] Using stored serum samples from the DPP, we tested whether circulating N-terminus-pro B-type natriuretic peptide (NT-proBNP) differed between race/ethnic groups at baseline and after two years of intervention.