ANXA5 and neoplasm: As the proposed mechanism possibly is also relevant for the combinatorial effects of radiation and tTF-NGR in vivo when tumor cells are forming smaller areas of the inner cell layer of the tumor neovasculature, we have repeated the experiment with HT1080 cells testing one Annexin V concentration, and observed an identical “masking effect” (Fig 4B; 2 independent experiments, n represents total numbers of assays of all experiments).