APOE and Alzheimer disease: Similarly, two recent phase 3 targeted trials of bapineuzumab selected 1331 AD participants who were not APOE ε4 carriers and 1121 who were APOE ε4 carriers based on the hypothesis that non-carriers were responsive to bapineuzumab, whereas carriers were not, did not achieve the expected reduction in AD assessment scale-cognitive subscale (ADAS-Cog11).