Notably, we observed that elevated expression in the highest quartile of CD3e (HR 0.51, 95% CI 0.29–0.91, P = 0.02), CD8a (HR 0.45, 95% CI 0.25–0.80, P = 0.006), IFN-γ (HR 0.50, 95% CI 0.28–0.89, P = 0.02), and perforin (PRF1, HR 0.42, 95% CI 0.22–0.80, P = 0.006) in human sarcomas were associated with greater OS. Here, PRF1 is linked to sarcoma.