PRF1 and neoplasm: In particular, we focused on genes associated with cytotoxic lymphocyte phenotype and function (CD3, CD8, Interferon-γ, Granzyme B, Perforin, and IL-2 receptor B/CD122) as well as IL-6 and IL-6 receptor given our serum ELISA and tumor PCR results for IL-6 (Figs 3 and 5).