TP53 and cancer: Finally, a GSEA analysis revealed that the key genes promoted cell proliferation as well as cancer development and progression via different cell cycle, DNA replication, mismatch repair, and cancer-associated pathways (e.g., phosphatidylinositol signaling system [41], basal cell carcinoma, transforming growth factor beta signaling pathway [42], WNT signaling pathway [43], and the p53 signaling pathway).