In order to refine the association between mutations and clinical data and to better define the MPM heterogeneity at the genetic level, we made a deep characterization of the mutations in 21 genes of interest selected based on literature data including the major MPM mutated genes (BAP1, NF2, TP53, SETD2, LATS2, etc.)and the TERT_prom using a collection of 266 MPM tumor samples with extended clinical annotations. The gene discussed is BAP1; the disease is neoplasm.