In this systematic review and network meta-analysis of 46 randomized clinical trials that performed direct comparisons of individual antihypertension medication classes among 248 887 patients with hypertension and no substantial comorbidities, angiotensin-converting enzyme inhibitors, dihydropyridine calcium channel blockers, and diuretics were reported to be similarly effective in reducing cardiovascular death, stroke, and overall cardiovascular events. The gene discussed is ACE; the disease is Stroke.