In this systematic review and network meta-analysis of 46 randomized clinical trials that performed direct comparisons of individual antihypertension medication classes among 248 887 patients with hypertension and no substantial comorbidities, angiotensin-converting enzyme inhibitors, dihydropyridine calcium channel blockers, and diuretics were reported to be similarly effective in reducing cardiovascular death, stroke, and overall cardiovascular events. This evidence concerns the gene ACE and stroke disorder.