For TP53 rs1042522, the carriers with CG (adjusted OR = 1.51, 95% CI = 1.00–2.29, P=0.051) or GG (adjusted OR = 1.11, 95% CI = 0.66–1.85, P=0.700) genotypes showed no significant association with Wilms tumor risk compared with carriers of the CC genotype. Here, TP53 is linked to Wilms tumor.