Dsg3 CAAR-T cells were the human T cells engineered to express a CAAR that consisted of the pemphigus vulgaris (PV) autoantigen and desmoglein 3 (Dsg3), fused to CD137-CD3ζ signaling domains, and were effective for PV relief without any off-target toxicity, specifically eliminating Dsg3-specific B cells, thus obviously decreasing Dsg3 serum autoantibody titers [42]. This evidence concerns the gene DSG3 and pemphigus vulgaris.